Haemozoin Induces Early Cytokine-Mediated Lysozyme Release from Human Monocytes through p38 MAPK- and NF-kappaB- Dependent Mechanisms

Malarial pigment (natural haemozoin, HZ) is a ferriprotoporphyrin IX crystal produced by Plasmodium parasites after haemoglobin catabolism. HZ-fed human monocytes are functionally compromised, releasing increased amounts of pro-inflammatory molecules, including cytokines, chemokines and cytokine-rel...

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Detalhes bibliográficos
Main Authors: Polimeni, Manuela, Valente, Elena, Aldieri, Elisabetta, Khadjavi, Amina, Giribaldi, Giuliana, Prato, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377659/
https://ncbi.nlm.nih.gov/pubmed/22724024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039497
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