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Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling

GRP78, a master regulator of the unfolded protein response (UPR) and cell signaling, is required for inner cell mass survival during early embryonic development. However, little is known about its role in adult hematopoietic stem cells (HSCs) and hematopoiesis. Here we generated a conditional knocko...

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Detalhes bibliográficos
Main Authors: Wey, Shiuan, Luo, Biquan, Lee, Amy S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377598/
https://ncbi.nlm.nih.gov/pubmed/22723926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039047
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