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Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling

GRP78, a master regulator of the unfolded protein response (UPR) and cell signaling, is required for inner cell mass survival during early embryonic development. However, little is known about its role in adult hematopoietic stem cells (HSCs) and hematopoiesis. Here we generated a conditional knocko...

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Detalles Bibliográficos
Autores principales: Wey, Shiuan, Luo, Biquan, Lee, Amy S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377598/
https://ncbi.nlm.nih.gov/pubmed/22723926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039047
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