TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family and is involved in cytokine signalling. In vitro analyses suggest that TYK2 also has kinase-independent, i.e., non-canonical, functions. We have generated gene-targeted mice harbouring a mutation in the ATP-binding pocket of the k...

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Detalhes bibliográficos
Main Authors: Prchal-Murphy, Michaela, Semper, Christian, Lassnig, Caroline, Wallner, Barbara, Gausterer, Christian, Teppner-Klymiuk, Ingeborg, Kobolak, Julianna, Müller, Simone, Kolbe, Thomas, Karaghiosoff, Marina, Dinnyés, Andras, Rülicke, Thomas, Leitner, Nicole R., Strobl, Birgit, Müller, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377589/
https://ncbi.nlm.nih.gov/pubmed/22723949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039141
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