Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats

Bromochloromethane (BCM) is a volatile compound and a by-product of disinfection of water by chlorination. Physiologically based pharmacokinetic (PBPK) models are used in risk assessment applications. An updated PBPK model for BCM is generated and applied to hypotheses testing calibrated using vapor...

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Main Authors: Cuello, W. S., Janes, T. A. T., Jessee, J. M., Venecek, M. A., Sawyer, M. E., Eklund, C. R., Evans, M. V.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377357/
https://ncbi.nlm.nih.gov/pubmed/22719758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/629781
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