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Tumor microenvironment in NSCLC suppresses NK cells function

NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms l...

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Detalhes bibliográficos
Main Authors: Cremer, Isabelle, Fridman, Wolf Herman, Sautès-Fridman, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377004/
https://ncbi.nlm.nih.gov/pubmed/22720258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.2.18309
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