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RhoB regulates cell migration through altered focal adhesion dynamics

The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active membrane ruffling around the periphery. Deple...

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מידע ביבליוגרפי
Main Authors: Vega, Francisco M., Colomba, Audrey, Reymond, Nicolas, Thomas, Mairian, Ridley, Anne J.
פורמט: Artigo
שפה:Inglês
יצא לאור: The Royal Society 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376739/
https://ncbi.nlm.nih.gov/pubmed/22724071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120076
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