RhoB regulates cell migration through altered focal adhesion dynamics

The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active membrane ruffling around the periphery. Deple...

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Bibliographic Details
Main Authors: Vega, Francisco M., Colomba, Audrey, Reymond, Nicolas, Thomas, Mairian, Ridley, Anne J.
Format: Artigo
Language:Inglês
Published: The Royal Society 2012
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376739/
https://ncbi.nlm.nih.gov/pubmed/22724071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120076
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