Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity and the mitochondrial ATP generation, redox state,...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Berndt, Nikolaus, Bulik, Sascha, Holzhütter, Hermann-Georg
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376505/
https://ncbi.nlm.nih.gov/pubmed/22719765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/757594
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares