Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity and the mitochondrial ATP generation, redox state,...

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Detalhes bibliográficos
Main Authors: Berndt, Nikolaus, Bulik, Sascha, Holzhütter, Hermann-Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376505/
https://ncbi.nlm.nih.gov/pubmed/22719765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/757594
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