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Selective ATP-competitive Inhibitors of TOR Suppress Rapamycin Insensitive Function of TORC2 in S. cerevisiae
The target of rapamycin (TOR) is a critical regulator of growth, survival and energy metabolism. The allosteric TORC1 inhibitor rapamycin has been used extensively to elucidate the TOR related signal pathway but is limited by its inability to inhibit TORC2. We used an unbiased cell proliferation ass...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376217/ https://ncbi.nlm.nih.gov/pubmed/22496512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300058v |
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