Transcriptional Dominance of Pax7 in Adult Myogenesis is Due to High-Affinity Recognition of Homeodomain Motifs

Pax3 and Pax7 regulate stem cell function in skeletal myogenesis. However, molecular insight into their distinct roles has remained elusive. Using gene expression data combined with genome wide binding-site analysis we show that both Pax3 and Pax7 bind identical DNA motifs and jointly activate a lar...

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Bibliografiske detaljer
Main Authors: Soleimani, Vahab D., Punch, Vincent G., Kawabe, Yoh-ichi, Jones, Andrew E., Palidwor, Gareth A., Porter, Christopher J., Cross, Joe W., Carvajal, Jaime J., Kockx, Christel E.M., van IJcken, Wilfred F.J., Perkins, Theodore J., Rigby, Peter W.J., Grosveld, Frank, Rudnicki, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376216/
https://ncbi.nlm.nih.gov/pubmed/22609161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.03.014
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