Snail Regulates MyoD Binding-Site Occupancy to Direct Enhancer Switching and Differentiation-Specific Transcription in Myogenesis

In skeletal myogenesis, the transcription factor MyoD activates distinct transcriptional programs in progenitors compared to terminally differentiated cells. Using ChIP-Seq and gene expression analyses, we show that in primary myoblasts, Snail-HDAC1/2 repressive complex binds and excludes MyoD from...

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Publicado no:Mol Cell
Main Authors: Soleimani, Vahab D., Yin, Hang, Jahani-Asl, Arezu, Ming, Hong, Kockx, Christel E.M., van Ijcken, Wilfred F.J., Grosveld, Frank, Rudnicki, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580277/
https://ncbi.nlm.nih.gov/pubmed/22771117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.046
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