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Mutasynthesis of a Potent Anticancer Sibiromycin Analog
Pursuit of the actinomycete pyrrolobenzodiazepine natural product sibiromycin as a chemotherapeutic agent has been limited by its cardiotoxicity. Among pyrrolobenzodiazepines, cardiotoxicity is associated with hydroxylation at position 9. Deletion of the methyltransferase gene sibL abolishes the pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376188/ https://ncbi.nlm.nih.gov/pubmed/22390171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200544u |
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