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Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic

Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds with significant antitumor properties. Among the pyrrolo[1,4]benzodiazepines (PBDs) sibiromycin, one of two identified glycosylated PBDs, displays the highest affinity for D...

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Autors principals: Li, Wei, Khullar, Ankush, Chou, ShenChieh, Sacramo, Ashley, Gerratana, Barbara
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681668/
https://ncbi.nlm.nih.gov/pubmed/19270142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02326-08
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