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Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic
Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds with significant antitumor properties. Among the pyrrolo[1,4]benzodiazepines (PBDs) sibiromycin, one of two identified glycosylated PBDs, displays the highest affinity for D...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681668/ https://ncbi.nlm.nih.gov/pubmed/19270142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02326-08 |
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