The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

Hypoxia is a microenvironmental factor that contributes to the invasion, progression and metastasis of tumor cells. Hypoxic tumor cells often show more resistance to conventional chemoradiotherapy than normoxic tumor cells, suggesting the requirement of novel antitumor therapies to efficiently elimi...

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Autors principals: Hashimoto, Yuuri, Tazawa, Hiroshi, Teraishi, Fuminori, Kojima, Toru, Watanabe, Yuichi, Uno, Futoshi, Yano, Shuya, Urata, Yasuo, Kagawa, Shunsuke, Fujiwara, Toshiyoshi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376103/
https://ncbi.nlm.nih.gov/pubmed/22720091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039292
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