JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

BACKGROUND: Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of deregulated androgen r...

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Detalhes bibliográficos
Main Authors: Laschak, Martin, Spindler, Klaus-Dieter, Schrader, Andres J, Hessenauer, Andrea, Streicher, Wolfgang, Schrader, Mark, Cronauer, Marcus V
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376035/
https://ncbi.nlm.nih.gov/pubmed/22462810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-130
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