Iron Inhibits Activation-induced Cytidine Deaminase Enzymatic Activity and Modulates Immunoglobulin Class Switch DNA Recombination

Immunoglobulin (Ig) class switch DNA recombination (CSR) and somatic hypermutation (SHM) are critical for the maturation of the antibody response. Activation-induced cytidine deaminase (AID) initiates CSR and SHM by deaminating deoxycytidines (dCs) in switch (S) and V(D)J region DNA, respectively, t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Li, Guideng, Pone, Egest J., Tran, Daniel C., Patel, Pina J., Dao, Lisa, Xu, Zhenming, Casali, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375573/
https://ncbi.nlm.nih.gov/pubmed/22556412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366732
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados