Detrimental Role for Human High Temperature Requirement Serine Protease A1 (HTRA1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration

Human HTRA1 is a highly conserved secreted serine protease that degrades numerous extracellular matrix proteins. We have previously identified HTRA1 as being up-regulated in osteoarthritic patients and as having the potential to regulate matrix metalloproteinase (MMP) expression in synovial fibrobla...

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Autors principals: Tiaden, André N., Klawitter, Marina, Lux, Vanda, Mirsaidi, Ali, Bahrenberg, Gregor, Glanz, Stephan, Quero, Lilian, Liebscher, Thomas, Wuertz, Karin, Ehrmann, Michael, Richards, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375554/
https://ncbi.nlm.nih.gov/pubmed/22556410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341032
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