Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

INTRODUCTION: Intervertebral disc (IVD) degeneration is characterized by extracellular matrix breakdown and is considered to be a primary cause of discogenic back pain. Although increases in pro-inflammatory cytokine levels within degenerating discs are associated with discogenic back pain, the mech...

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Главные авторы: Quero, Lilian, Klawitter, Marina, Schmaus, Anja, Rothley, Melanie, Sleeman, Jonathan, Tiaden, André N, Klasen, Juergen, Boos, Norbert, Hottiger, Michael O, Wuertz, Karin, Richards, Peter J
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978638/
https://ncbi.nlm.nih.gov/pubmed/23968377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4274
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