New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase (IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to LEDGINs. LEDGINs are a class of potent antiviral compounds that interacts with the lens epithelium-derived g...

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Dettagli Bibliografici
Autori principali: Tsiang, Manuel, Jones, Gregg S., Niedziela-Majka, Anita, Kan, Elaine, Lansdon, Eric B., Huang, Wayne, Hung, Magdeleine, Samuel, Dharmaraj, Novikov, Nikolai, Xu, Yili, Mitchell, Michael, Guo, Hongyan, Babaoglu, Kerim, Liu, Xiaohong, Geleziunas, Romas, Sakowicz, Roman
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375541/
https://ncbi.nlm.nih.gov/pubmed/22535962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347534
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