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NAD(+) Levels Control Ca(2+) Store Replenishment and Mitogen-induced Increase of Cytosolic Ca(2+) by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes
Intracellular NAD(+) levels ([NAD(+)](i)) are important in regulating human T lymphocyte survival, cytokine secretion, and the capacity to respond to antigenic stimuli. NAD(+)-derived Ca(2+)-mobilizing second messengers, produced by CD38, play a pivotal role in T cell activation. Here we demonstrate...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375530/ https://ncbi.nlm.nih.gov/pubmed/22547068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324269 |
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