NAD(+) Levels Control Ca(2+) Store Replenishment and Mitogen-induced Increase of Cytosolic Ca(2+) by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes

Intracellular NAD(+) levels ([NAD(+)](i)) are important in regulating human T lymphocyte survival, cytokine secretion, and the capacity to respond to antigenic stimuli. NAD(+)-derived Ca(2+)-mobilizing second messengers, produced by CD38, play a pivotal role in T cell activation. Here we demonstrate...

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Hlavní autoři: Magnone, Mirko, Bauer, Inga, Poggi, Alessandro, Mannino, Elena, Sturla, Laura, Brini, Marisa, Zocchi, Elena, De Flora, Antonio, Nencioni, Alessio, Bruzzone, Santina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375530/
https://ncbi.nlm.nih.gov/pubmed/22547068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324269
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