Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold

SHARPIN (SHANK-associated RH domain interacting protein) is part of a large multi-protein E3 ubiquitin ligase complex called LUBAC (linear ubiquitin chain assembly complex), which catalyzes the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways. The C-terminal...

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Bibliografiske detaljer
Main Authors: Stieglitz, Benjamin, Haire, Lesley F., Dikic, Ivan, Rittinger, Katrin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375506/
https://ncbi.nlm.nih.gov/pubmed/22549881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359547
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