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Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis
Aurachin RE (1) is a strong antibiotic that was recently found to possess MenA (1,4-dihydroxy-2-naphthoate prenyltransferase) and bacterial electron transport inhibitory activities. Aurachin RE is the only molecule in a series of aurachin natural products that has the chiral center in the alkyl side...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375340/ https://ncbi.nlm.nih.gov/pubmed/22449052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201608g |
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