Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

Aurachin RE (1) is a strong antibiotic that was recently found to possess MenA (1,4-dihydroxy-2-naphthoate prenyltransferase) and bacterial electron transport inhibitory activities. Aurachin RE is the only molecule in a series of aurachin natural products that has the chiral center in the alkyl side...

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Bibliographic Details
Main Authors:	Debnath, Joy, Siricilla, Shajila, Wan, Bajoie, Crick, Dean C., Lenaerts, Anne J., Franzblau, Scott G., Kurosu, Michio
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3375340/ https://ncbi.nlm.nih.gov/pubmed/22449052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201608g
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Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

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