Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

Small differences in the chemical structures of ligands can be responsible for agonism, neutral antagonism or inverse agonism toward a G-protein-coupled receptor (GPCR). Although each ligand may stabilize the receptor conformation in a different way, little is known about the precise conformational...

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Main Authors: Miura, Shin-ichiro, Kiya, Yoshihiro, Hanzawa, Hiroyuki, Nakao, Naoki, Fujino, Masahiro, Imaizumi, Satoshi, Matsuo, Yoshino, Yanagisawa, Hiroaki, Koike, Hiroyuki, Komuro, Issei, Karnik, Sadashiva S., Saku, Keijiro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375280/
https://ncbi.nlm.nih.gov/pubmed/22719858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037974
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