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Differential Bonding Interactions of Inverse Agonists of Angiotensin II Type 1 Receptor in Stabilizing the Inactive State

Although the sartan family of angiotensin II type 1 (AT(1)) receptor blockers (ARBs), which includes valsartan, olmesartan, and losartan, have a common pharmacophore structure, their effectiveness in therapy differs. Although their efficacy may be related to their binding strength, this notion has c...

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Detalhes bibliográficos
Main Authors: Miura, Shin-ichiro, Kiya, Yoshihiro, Kanazawa, Takanori, Imaizumi, Satoshi, Fujino, Masahiro, Matsuo, Yoshino, Karnik, Sadashiva S., Saku, Keijiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725753/
https://ncbi.nlm.nih.gov/pubmed/17901125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0312
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