Abilities of candesartan and other AT(1) receptor blockers to impair angiotensin II-induced AT(1) receptor activation after wash-out

Angiotensin II (Ang II) binds to Ang II type 1 (AT(1)) receptor and evokes cell signaling, and subsequently stimulates vasoconstriction and cell proliferation, which eventually lead to cardiovascular disease. Since most AT(1) receptor blockers (ARBs) have molecular (differential) effects, we evaluat...

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Bibliographic Details
Main Authors: Kiya, Yoshihiro, Miura, Shin-ichiro, Matsuo, Yoshino, Karnik, Sadashiva S, Saku, Keijiro
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891522/
https://ncbi.nlm.nih.gov/pubmed/21824992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1470320311417478
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