Inflammatory Bowel Diseases Phenotype, C. difficile and NOD2 Genotype Are Associated with Shifts in Human Ileum Associated Microbial Composition

We tested the hypothesis that Crohn’s disease (CD)-related genetic polymorphisms involved in host innate immunity are associated with shifts in human ileum–associated microbial composition in a cross-sectional analysis of human ileal samples. Sanger sequencing of the bacterial 16S ribosomal RNA (rRN...

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Main Authors: Li, Ellen, Hamm, Christina M., Gulati, Ajay S., Sartor, R. Balfour, Chen, Hongyan, Wu, Xiao, Zhang, Tianyi, Rohlf, F. James, Zhu, Wei, Gu, Chi, Robertson, Charles E., Pace, Norman R., Boedeker, Edgar C., Harpaz, Noam, Yuan, Jeffrey, Weinstock, George M., Sodergren, Erica, Frank, Daniel N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374607/
https://ncbi.nlm.nih.gov/pubmed/22719818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026284
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