Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin

[Image: see text] Novel sources of antibiotics are required to keep pace with the inevitable onset of bacterial resistance. Continuing with our macrolide desmethylation strategy as a source of new antibiotics, we report the total synthesis, molecular modeling, and biological evaluation of 4,10-dides...

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Autori principali: Velvadapu, Venkata, Glassford, Ian, Lee, Miseon, Paul, Tapas, DeBrosse, Charles, Klepacki, Dorota, Small, Meagan C., MacKerell, Alexander D., Andrade, Rodrigo B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374412/
https://ncbi.nlm.nih.gov/pubmed/22708010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200254h
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