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Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening
Mortalin was over expressed in tumor cells and bind to p53 protein. This interaction was suggested to promote sequestration of p53 in the cytoplasm, thereby inhibiting its nuclear activity. The p53 is a tumor suppressor that is essential for the prevention of cancer development and loss of p53 funct...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biomedical Informatics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3374373/ https://ncbi.nlm.nih.gov/pubmed/22715313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630008426 |
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