Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1

Inactivation of the retinoblastoma protein (pRb) by phosphorylation triggers uncontrolled cell proliferation. Accordingly, activation of cyclin-dependent kinase (CDK)/cyclin complexes or downregulation of CDK inhibitors appears as a common event in human cancer. Here we show that Pin1 (protein inter...

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Autors principals: Rizzolio, F, Lucchetti, C, Caligiuri, I, Marchesi, I, Caputo, M, Klein-Szanto, A J, Bagella, L, Castronovo, M, Giordano, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374078/
https://ncbi.nlm.nih.gov/pubmed/22322860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.202
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