Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1

Inactivation of the retinoblastoma protein (pRb) by phosphorylation triggers uncontrolled cell proliferation. Accordingly, activation of cyclin-dependent kinase (CDK)/cyclin complexes or downregulation of CDK inhibitors appears as a common event in human cancer. Here we show that Pin1 (protein inter...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Rizzolio, F, Lucchetti, C, Caligiuri, I, Marchesi, I, Caputo, M, Klein-Szanto, A J, Bagella, L, Castronovo, M, Giordano, A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2012
Onderwerpen:
Original Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374078/
https://ncbi.nlm.nih.gov/pubmed/22322860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.202
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items