Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease

BACKGROUND: Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory...

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Detalhes bibliográficos
Main Authors: de Oliveira, Fabiane L., Araújo-Jorge, Tania C., de Souza, Elen M., de Oliveira, Gabriel M., Degrave, Wim M., Feige, Jean-Jacques, Bailly, Sabine, Waghabi, Mariana C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373641/
https://ncbi.nlm.nih.gov/pubmed/22720109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001696
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