TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas’ heart disease

TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling pathway is activated in the cardiac tissue of chronic phase patients and is associated with an increase in extracellular matrix protein expression. The aim of this study was to investigate the effec...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Vilar-Pereira, Glaucia, Degrave, Wim, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, da Cruz Moreira, Otacílio, da Silva Gomes, Natália Lins, Mello de Souza, Elen, Ramos, Isalira P., Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C., Waghabi, Mariana Caldas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690554/
https://ncbi.nlm.nih.gov/pubmed/31365537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007602
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