TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas’ heart disease

TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling pathway is activated in the cardiac tissue of chronic phase patients and is associated with an increase in extracellular matrix protein expression. The aim of this study was to investigate the effec...

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Библиографические подробности
Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Vilar-Pereira, Glaucia, Degrave, Wim, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, da Cruz Moreira, Otacílio, da Silva Gomes, Natália Lins, Mello de Souza, Elen, Ramos, Isalira P., Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C., Waghabi, Mariana Caldas
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690554/
https://ncbi.nlm.nih.gov/pubmed/31365537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007602
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