Footprint of Positive Selection in Treponema pallidum subsp. pallidum Genome Sequences Suggests Adaptive Microevolution of the Syphilis Pathogen

In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulence...

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Главные авторы: Giacani, Lorenzo, Chattopadhyay, Sujay, Centurion-Lara, Arturo, Jeffrey, Brendan M., Le, Hoavan T., Molini, Barbara J., Lukehart, Sheila A., Sokurenko, Evgeni V., Rockey, Daniel D.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373638/
https://ncbi.nlm.nih.gov/pubmed/22720110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001698
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