Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

The purpose of this study was to investigate the protective effects of the mitochondria-targeted antioxidant catalase (MCAT) and lifespan extension in mice that express amyloid beta (Aβ). Using immunoblotting and immunostaining analyses, we measured the production of full-length amyloid precursor pr...

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Detaylı Bibliyografya
Asıl Yazarlar: Mao, Peizhong, Manczak, Maria, Calkins, Marcus J., Truong, Quang, Reddy, Tejaswini P., Reddy, Arubala P., Shirendeb, Ulziibat, Lo, Herng-Hsiang, Rabinovitch, Peter S., Reddy, P. Hemachandra
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2012
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373244/
https://ncbi.nlm.nih.gov/pubmed/22492996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds128
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