Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1

Lipoprotein lipase (LPL) is a 448-amino-acid head-to-tail dimeric enzyme that hydrolyzes triglycerides within capillaries. LPL is secreted by parenchymal cells into the interstitial spaces; it then binds to GPIHBP1 (glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1) on...

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Main Authors: Gin, Peter, Goulbourne, Chris N., Adeyo, Oludotun, Beigneux, Anne P., Davies, Brandon S. J., Tat, Shelly, Voss, Constance V., Bensadoun, André, Fong, Loren G., Young, Stephen G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373243/
https://ncbi.nlm.nih.gov/pubmed/22493000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds127
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