Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1

GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells, shuttles lipoprotein lipase (LPL) from subendothelial spaces to the capillary lumen. An absence of GPIHBP1 prevents the entry of LPL into capillaries, blocking LPL-mediated triglyceride hydrolysis and leading to...

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Main Authors: Voss, Constance V., Davies, Brandon S. J., Tat, Shelly, Gin, Peter, Fong, Loren G., Pelletier, Christopher, Mottler, Charlene D., Bensadoun, André, Beigneux, Anne P., Young, Stephen G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093490/
https://ncbi.nlm.nih.gov/pubmed/21518912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100992108
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