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Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
The abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and correlates with cognitive decline in Alzheimer's disease. The ubiquitin ligase carboxy terminus of Hsp70-interacting protein (CHIP) and the molecular chaperone Hsp90...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373241/ https://ncbi.nlm.nih.gov/pubmed/22492994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds125 |
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