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Thermodynamic principles for the engineering of pH-driven conformational switches and acid insensitive proteins
The general thermodynamic principles behind pH driven conformational transitions of biological macromolecules are well understood. What is less obvious is how they can be used to engineer pH switches in proteins. The acid unfolding of staphylococcal nuclease (SNase) was used to illustrate different...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373021/ https://ncbi.nlm.nih.gov/pubmed/21802194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.06.016 |
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