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Normalization, testing, and false discovery rate estimation for RNA-sequencing data

We discuss the identification of genes that are associated with an outcome in RNA sequencing and other sequence-based comparative genomic experiments. RNA-sequencing data take the form of counts, so models based on the Gaussian distribution are unsuitable. Moreover, normalization is challenging beca...

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Hlavní autoři: Li, Jun, Witten, Daniela M., Johnstone, Iain M., Tibshirani, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372940/
https://ncbi.nlm.nih.gov/pubmed/22003245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxr031
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