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Normalization, testing, and false discovery rate estimation for RNA-sequencing data
We discuss the identification of genes that are associated with an outcome in RNA sequencing and other sequence-based comparative genomic experiments. RNA-sequencing data take the form of counts, so models based on the Gaussian distribution are unsuitable. Moreover, normalization is challenging beca...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372940/ https://ncbi.nlm.nih.gov/pubmed/22003245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxr031 |
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