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False discovery rates for rare variants from sequenced data

The detection of rare deleterious variants is the pre-eminent current technical challenge in statistical genetics. Sorting the deleterious from neutral variants at a disease locus is challenging because of the sparseness of the evidence for each individual variant. Hierarchical modeling and Bayesian...

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Publicat a:Genet Epidemiol
Autors principals: Capanu, Marinela, Seshan, Venkatraman E.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711769/
https://ncbi.nlm.nih.gov/pubmed/25556339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21880
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