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RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity

Although protein-mediated toxicity in neurological disease has been extensively characterized, RNA-mediated toxicity is an emerging mechanism of pathogenesis. In microsatellite expansion disorders, expansion of repeated sequences in noncoding regions gives rise to RNA that produces a toxic gain of f...

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Autors principals: Echeverria, Gloria V., Cooper, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372679/
https://ncbi.nlm.nih.gov/pubmed/22405728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2012.02.030
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