Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D(3) function in human colon adenocarcinoma LS180 cells

Oxidative catabolism of 1α,25-dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)] is mediated by either CYP24A1 or CYP3A4. In this paper, we tested whether induction of CYP3A4 in the LS180 intestinal cell model enhances clearance of 1α,25(OH)(2)D(3) and blunts its hormonal effect on expression of the apical me...

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Autors principals: Zheng, Xi Emily, Wang, Zhican, Liao, Michael Z., Lin, Yvonne S., Shuhart, Margaret C., Schuetz, Erin G., Thummel, Kenneth E.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372629/
https://ncbi.nlm.nih.gov/pubmed/22562045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.04.019
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