Identification of Human UDP-glucuronosyltransferases Catalyzing Hepatic 1α,25-Dihydroxyvitamin D(3) Conjugation

The biological effects of 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are terminated primarily by P450-dependent hydroxylation reactions. However, the hormone is also conjugated in the liver and a metabolite, presumably a glucuronide, undergoes enterohepatic cycling. In this study, the identity of...

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Main Authors: Hashizume, Takanori, Xu, Yang, Mohutsky, Michael A., Alberts, Jeffrey, Hadden, Chad, Kalhorn, Thomas F., Isoherranen, Nina, Shuhart, Margaret C., Thummel, Kenneth E.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664830/
https://ncbi.nlm.nih.gov/pubmed/18177842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.11.008
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