Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D(3) through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia

Long-term therapy with certain drugs, especially P450 inducing agents, confers an increased risk of osteomalacia that is attributed to vitamin D deficiency. Human CYP24A1, CYP3A4 and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse drug response....

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Main Authors: Wang, Zhican, Lin, Yvonne S., Dickmann, Leslie J., Poulton, Emma-Jane, Eaton, David L., Lampe, Johanna W., Shen, Danny D., Davis, Connie L., Shuhart, Margaret C., Thummel, Kenneth E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609874/
https://ncbi.nlm.nih.gov/pubmed/23212742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1839
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