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Soluble Adenylyl Cyclase Activity Is Necessary for Retinal Ganglion Cell Survival and Axon Growth

cAMP is a critical second messenger mediating activity-dependent neuronal survival and neurite growth. We investigated the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion cells (RGCs). We found sAC protein expressed in multiple RGC compartments including...

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Autors principals: Corredor, Raul G., Trakhtenberg, Ephraim F., Pita-Thomas, Wolfgang, Jin, Xiaolu, Hu, Ying, Goldberg, Jeffrey L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372574/
https://ncbi.nlm.nih.gov/pubmed/22649251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5288-11.2012
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