TIMP-1 Induces an EMT-Like Phenotypic Conversion in MDCK Cells Independent of Its MMP-Inhibitory Domain

Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) regulate epithelial-mesenchymal transition (EMT) critical for the development of epithelial organs as well as cancer cell invasion. TIMP-1 is frequently overexpressed in several types of human cancers and serves as a prognostic...

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Detalhes bibliográficos
Main Authors: Jung, Young Suk, Liu, Xu-Wen, Chirco, Rosemarie, Warner, Richard B., Fridman, Rafael, Kim, Hyeong-Reh Choi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372473/
https://ncbi.nlm.nih.gov/pubmed/22701711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038773
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