TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.

The matrix metalloproteinase (MMP)-2 has a crucial role in extracellular matrix degradation associated with cancer metastasis and angiogenesis. The latent form, pro-MMP-2, is activated on the cell surface by the membrane-tethered membrane type 1 (MT1)-MMP, in a process regulated by the tissue inhibi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Bernardo, M Margarida, Fridman, Rafael
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223627/
https://ncbi.nlm.nih.gov/pubmed/12755684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030557
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker